EFFECTS OF HIGH DOSED LONG ACTING OXYTETRACYCLINE ON SOME HAEMOTOLOGICAL INDICES IN GOATS

Abstract

The present study assessed effects of high dosed long acting oxytetracycline (Oxy LA) on some haemotological indices in six goats. Each goat was intramuscularly administered with a high dose (30 mg/kg BW) of Oxy LA for the period of 07 days with an interval of 48 hours. The blood samples were taken at different time-points from 0-148 h after final dose of Oxy LA for the assessment of haemotological indices. The results showed that Oxy LA administration  significantly decreased (p< 0.05) leucocytes count at various time points from 6 to 120 h and the decrease in leucocyte count was highly significant (P< 0.01) at 72 and 96 h post-administration. Oxy LA treatment caused significant decrease (P< 0.05) in the lymphocytes count (1000/cu.mm)  at all observed time-points from 6 to 148 h and the decrease in lymphocyte count was highly significant (P< 0.01) at various time points from 12 to 120 h. Significant decrease in the RBC count (millions/cu.mm), haemoglobin concentration (g/dl) and packed cell volume (PCV, %) was recorded at 24, 120, 148 h (P< 0.05) and at 48, 72, 96 h (P< 0.01) after administration of high dosed Oxy LA. Maximum decrease in RBC count, haemoglobin level and PCV occurred at 72 h post-administration.